Emploi Pays-Bas
PhD Position in Smart Biomaterials Through Dynamic Covalent Chemistry
Entreprise : Maastricht University
Description du poste
Welcome to Maastricht University! Au sein de cette institution, nous sommes déterminés à transformer la recherche et l’éducation, en mettant l’accent sur l’innovation collaborative. Nous recherchons un candidat enthousiaste pour rejoindre notre équipe interdisciplinaire consacrée à la chimie dynamique et aux biomatériaux.
Aperçu du projet
Nous proposons un poste de doctorant entièrement financé de 4 ans. Ce rôle est destiné à un chimiste organique/polymer qui souhaite établir un impact significatif dans le domaine des biomatériaux. Le projet vise à concevoir des biomatériaux multi-réactifs en intégrant la synthèse polymère, la chimie covalente dynamique, et les réactions bio-click. L’objectif principal est de développer des réseaux d’hydrogel adaptables topologiquement, capables de répondre à divers stimuli externes (pH, redox, température) et de permettre une libération contrôlée de médicaments pour des applications en ingénierie tissulaire et médecine régénérative.
Objectifs scientifiques
Les responsabilités incluront :
- Élaboration de stratégies synthétiques utilisant la synthèse dirigée par gabarit pour organiser spatialement les moitiés réactives dans les réseaux polymères.
- Exploration de la transformation topologique et du réarrangement du réseau pour obtenir un comportement matériel réactif.
- Refinement des cinétiques de libération de médicaments via des mécanismes covalents et supramoléculaires.
- Établissement de relations structure-propriété grâce à des outils analytiques avancés.
- Application de vos travaux à des défis biomédicaux concrets.
Contexte scientifique
Les systèmes covalents dynamiques offrent une voie unique vers des matériaux adaptables, inspirée par les interactions naturelles qui régissent la structure et la fonction des biomolécules. Ce projet se fonde sur l’effet de gabarit et la proximité spatiale contrôlée des réactants pour améliorer la réactivité et la sélectivité lors de la formation des liaisons covalentes.
Critères requis
Nous recherchons un chercheur créatif, motivé par l’application des principes chimiques à des défis biomédicaux, avec les qualifications suivantes :
- Détention d’un diplôme de maîtrise (MSc ou équivalent) en chimie, science des matériaux ou domaine connexe.
- Expérience en synthèse organique et/ou polymère et caractérisation des matériaux.
- Maîtrise des outils tels que la RMN, la GPC, la rhéologie, la microscopie et les tests mécaniques.
- Ouverture à la collaboration interdisciplinaire et à l’échange de connaissances.
Des compétences en communication scientifique en anglais sont indispensables, tandis que la connaissance du néerlandais n’est pas requise.
Offre
En tant que doctorant à la Faculté de la santé, de la médecine et des sciences de la vie, vous bénéficierez d’un cadre international privilégié à Maastricht, avec :
- Des conditions d’emploi avantageuses, un salaire initial de 2901 € et atteignant 3707 € au cours de la quatrième année, en plus d’une prime de vacances et d’un bonus de fin d’année.
- Un contrat à durée déterminée de 12 mois, pouvant être prolongé de 3 ans après évaluation positive.
- Flexibilité dans les horaires de travail, options de télétravail, et un large éventail de jours de congé.
- Des opportunités de développement personnel et professionnel par le biais de programmes de formation variés.
À propos de Maastricht University
À Maastricht University (UM), nous travaillons pour l’avenir de nos étudiants et pour la société en général, abordant des défis mondiaux avec une approche interdisciplinaire. Avec plus de 22 300 étudiants et 5 000 employés, UM constitue une communauté dynamique et inspirante.
Établissement de la Faculté de la santé, de la médecine et des sciences de la vie
La faculté se consacre à la promotion d’un mode de vie sain, mettant l’accent sur la prévention et la préservation de la santé. Elle allie recherche, éducation et soins, en collaboration étroite avec l’hôpital universitaire de Maastricht.
Postuler pour ce poste
Si vous êtes passionné par l’utilisation de la chimie dans la résolution des défis biomédicaux, nous serions ravis d’examiner votre candidature, peu importe votre parcours. Pour en savoir plus et postuler, c’est ici.
Salaire attendu : 3707 € par mois
Localisation : Maastricht, Limburg
Date de publication : 12 juillet 2025
Status : Expiré
📅 Date de publication de l’offre : Sat, 12 Jul 2025 05:48:09 GMT
🏢 Entreprise :
📍 Lieu : Maastricht, Limburg
💼 Intitulé du poste : PhD Position in Smart Biomaterials Through Dynamic Covalent Chemistry
💶 Rémunération proposée : €3707 per month
📝 Description du poste : Offer DescriptionWelcome to Maastricht University!
At Maastricht University, we push boundaries in research and education – and we do it together. In our growing interdisciplinary research team, you’ll be at the heart of innovation in biomaterials and dynamic covalent chemistry. Join us as a PhD candidate and help shape the future of responsive, biofunctional materials for next-generation biomedical applications.About the project
We are offering a fully funded, 4-year PhD position for a talented and motivated organic/polymer chemist to join our young and collaborative lab. As we shape our scientific direction and lab culture, you’ll have the opportunity to help build something meaningful from the ground up.This project aims to design multi-responsive, dynamic biomaterials by integrating polymer synthesis, dynamic covalent chemistry, and bio-click reactions. The goal is to create topologically adaptable hydrogel networks that respond to external stimuli (e.g. pH, redox, temperature) and enable controlled drug release for use in tissue engineering and regenerative medicine.A particular focus will be the development of extracellular matrix (ECM)-like environments that support the growth and function of organoids and engineered tissues.Scientific goals
You will work on:
- Developing synthetic strategies using template-directed synthesis to spatially organize reactive moieties in polymer networks.
- Exploring topology transformation and network rearrangement to achieve responsive material behavior.
- Tuning drug release kinetics through covalent and supramolecular mechanisms.
- Establishing structure-property relationships using advanced analytical tools.
- Applying your work to real-world biomedical challenges.
Scientific background
Dynamic covalent systems offer a unique route to reversible and adaptable materials. Inspired by nature-where dynamic covalent interactions govern the structure and function of biomolecules, and templated reactions are part of everyday molecular life-we aim to harness similar principles for material design.By combining template effects with controlled spatial proximity of reactants, this project seeks to enhance reactivity and selectivity in covalent bond formation. Through this approach, we will explore how molecular design and processing conditions guide the assembly and adaptability of polymer networks, ultimately leading to biofunctional materials that reflect the complexity and responsiveness of living tissues.Key references:Schauenburg, D. & Weil, T. Not so bioorthogonal chemistry. J. Am. Chem. Soc. 147, 8049-8062 (2025)Rijns, L., Baker, M.B., & Dankers, P.Y.W. Using chemistry to recreate the complexity of the ECM. J. Am. Chem. Soc. 146, 17539-17558 (2024)Schauenburg, D. & Weil, T. Chemical Reactions in Living Systems. Adv. Sci. 11, 2303396 (2024)What you bring
We are looking for a creative and driven researcher who’s eager to apply chemical principles to biomedical challenges. You should:
- Hold a Master’s degree (MSc or equivalent) in Chemistry, Materials Science, or a related field.
- Have experience in organic and/or polymer synthesis and materials characterization.
- Be comfortable using tools like NMR, GPC, rheology, microscopy, and mechanical testing.
- Be open to interdisciplinary teamwork and knowledge exchange
Excellent scientific communication skills in English are essential. Dutch language skills are not required.If you’re enthusiastic about using chemistry to solve biomedical challenges, we’d love to hear from you-regardless of your background or where you’re from.What we offer
As a PhD candidateat the Faculty of Health, Medicine and Life Sciences, you will be employed by the most international university in the Netherlands, located in the beautiful city of Maastricht. In addition, we offer you:
- Good employment conditions. The position is graded according to UFO profile PhD, with corresponding salary from €2901,00 in the first year and €3707,00 gross per month in the fourth year (based on a full-time employment of 38 hours per week). In addition to the monthly salary, an 8.0% holiday allowance and an 8.3% year-end bonus apply.
- An employment contract for a period of 12 months with a scope of 1,0 FTE. Upon a positive evaluation, an extension of 3 years will follow.
- At Maastricht University, the well-being of our employees is of utmost importance, we offer flexible working hours and the possibility to work partly from home if the nature of your position allows it. You will receive a monthly commuting and internet allowance for this. If you work full-time, you will be entitled to 29 vacation days and 4 additional public holidays per year, namely carnival Monday, carnival Tuesday, Good Friday, and Liberation Day. If you choose to accumulate compensation hours, an additional 12 days will be added. Furthermore, you can personalize your employment conditions through a collective labor agreement (CAO) choice model.
- As Maastricht University, we offer various other excellent secondary employment conditions. These include a good pension scheme with the ABP and the opportunity for UM employees to participate in company fitness and make use of the extensive sports facilities that we also offer to our students.
- Last but certainly not least, we provide the space and facilities for your personal and professional development. We facilitate this by offering a wide range of training programs and supporting various well-established initiatives such as ‘acknowledge and appreciate’.
The terms of employment at Maastricht University are largely set out in the collective labor agreement of Dutch Universities. In addition, local provisions specific to UM apply. For more information, .Maastricht University
Why work at Maastricht University?At Maastricht University (UM), everything revolves around the future. The future of our students, as we work to equip them with a solid, broad-based foundation for the rest of their lives. And the future of society, as we seek solutions through our research to issues from all around the world. Our six faculties combined provide a comprehensive package of study programmes and research.In our teaching, we use the Problem-Based Learning (PBL) method. Students work in small groups, looking for solutions to problems themselves. By discussing issues and working together to draw conclusions, formulate answers and present them to their peers, students develop essential skills for their future careers.With over 22,300 students and more than 5,000 employees from all over the world, UM is home to a vibrant and inspiring international community.Are you drawn to an international setting focused on education, science and scholarship? Are you keen to contribute however your skills and qualities allow? Our door is open to you! As a young European university, we value your talent and look forward to creating the future together.for more information about UM.Faculty of Health, Medicine and Life Sciences
At the Faculty of Health, Medicine and Life Sciences (FHML), everything revolves around healthy living. Our research and education are not solely focused on recovery, but place a strong emphasis on prevention, health preservation, and health promotion. Our aim is to use our knowledge and expertise to genuinely contribute to the well-being of individual people as well as society in total.In, research, and healthcare, FHML is closely collaborating with the academic hospital in Maastricht, together forming the Maastricht University Medical Center (MUMC+). FHML is strongly connected in education, research, and care with the Maastricht academic hospital, together with which it forms the Maastricht University Medical Centre (MUMC+).FHML, which is the largest faculty of Maastricht University, is formed by an (inter)national community of employees and students. The faculty offers a wide range of and master’s programs in innovative educational concepts in which the emphasis is always on building bridges to practice.The multidisciplinary research of the FHML focuses on a number of carefully chosen topical current themes. In addition to research aimed at gaining new insights, it also concerns research whose results can be directly translated into concrete applications and innovations. The implementation of the various research programs is organized in ourWhere to apply WebsiteRequirementsAdditional InformationWebsite for additional job detailsWork Location(s)Number of offers available 1 Company/Institute Maastricht University Country Netherlands City Maastricht Postal Code 6229HX Street P. Debyelaan 25 GeofieldContact CityMaastricht WebsiteStreetMinderbroedersberg 4 Postal Code6211 LKSTATUS: EXPIREDShare this page
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